معرفی
Gregory Lang serves as a Professor and PhD Program Director in the Department of Biological Sciences at Lehigh University's College of Arts and Sciences. His laboratory is located in Iacocca Hall on Lehigh's Mountaintop Campus in Bethlehem, Pennsylvania. Lang directs an active research program focused on experimental evolution using Saccharomyces cerevisiae as a model system.
Lang's research spans three primary areas of investigation: Genetic Interactions, where his lab develops high-throughput methods to quantify fitness effects of mutations; Ploidy and Evolution, examining how ploidy states affect adaptation rates and evolutionary trajectories; and Genetic Conflict, studying intragenomic conflicts including sexual conflict, gene drive, and the yeast Killer virus system. His work sits at the intersection of evolutionary biology, molecular biology, and quantitative genetics, with practical implications for understanding human disease mechanisms and evolutionary constraints.
Analysis of Lang's publication record reveals consistent focus on mutation dynamics, adaptation patterns, and evolutionary constraints in yeast systems. His research demonstrates how genetic hitchhiking, epistasis, and ploidy changes shape evolutionary outcomes. The work frequently employs large-scale experimental evolution approaches with replicate populations to uncover general principles of molecular evolution. Recent publications emphasize genetic interaction networks and their role in constraining evolutionary paths.
- R01 grant to study genetic interactions in the context of experimental evolution
Lang actively mentors students and postdoctoral researchers, with recent additions to his lab including post-docs Dimitra Aggeli and Han-Ying Jhuang, and graduate student Artemiza Martinez. His lab maintains strong collaborative relationships, particularly with the Desai lab at Harvard, as evidenced by numerous co-authored publications. The Lang Lab has secured significant research funding, including an R01 grant for their work on genetic interactions.
The Lang Lab operates within Lehigh University's Department of Biological Sciences, utilizing specialized facilities including microscopy, cell culture, and flow cytometry resources. The lab maintains an active research agenda with regular publications and presentations, including a notable talk at the Kavli Institute for Theoretical Physics (KITP) in Santa Barbara.
