Giuseppe Testa

Giuseppe Testa is a Professor of Molecular Biology at the University of Milan and Director of the High Definition Disease Modelling Lab (Stem Cell and Organoid Epigenetics) at the European Institute of Oncology. He leads the Neurogenomics Centre at Human Technopole, focusing on molecular mechanisms of intellectual disabilities and autism through cutting-edge iPSC and 3D organoid modeling.

• Affiliations: University of Milan, European Institute of Oncology (IEO), Human Technopole
• Research Themes: Epigenetic regulation in neurodevelopmental disorders, gene-environment interactions in ASD, CRISPR/organoid modeling, enhanceropathies, modern human evolution via gene networks

His publications highlight cross-disciplinary approaches combining single-cell omics, 3D brain organoids, and environmental toxicology to unravel 7q11.23 CNVs, CHD8 haploinsufficiency, and endocrine disruptor impacts. The 2023 Cell Reports Medicine study reveals SARS-CoV-2's neuroinflammatory mechanisms via RAGE receptors, while 2022 works in Nature and Cell Reports establish organoid standards and ASD neuronal timing defects.

Key Techniques: Human iPSC reprogramming, CRISPR epigenome editing, multi-omics integration, high-throughput drug screening