معرفی
Dr. Girish Shukla is a Professor at Cleveland State University affiliated with the Center for Gene Regulation in Health and Disease (GRHD), focusing on molecular mechanisms of eukaryotic gene expression at the RNA level. His research spans RNA biology, cancer therapeutics, and gene regulation.
His primary research interests include:
- Molecular mechanisms of eukaryotic gene expression at the RNA level
- Noncoding RNAs and their regulatory roles
- Nuclear pre-mRNA splicing and minor spliceosome dynamics
- RNA:RNA and RNA:Protein interactions
- Post-transcriptional control in prostate cancer
- miRNA-mediated androgen receptor regulation
- Steroid biosynthesis pathways as cancer therapeutic targets
Analysis of Dr. Shukla's recent publications reveals a strong emphasis on microRNA regulation in prostate cancer progression, with significant work on androgen receptor control mechanisms. His research increasingly integrates computational biology with molecular approaches to identify cancer biomarkers and therapeutic targets, particularly in RNA metabolism and noncoding RNA functions. The publications demonstrate consistent contributions to understanding spliceosomal mechanisms and their dysregulation in hematological cancers.
Dr. Shukla actively mentors graduate researchers, including PhD student Asmita Bhattarai, within the GRHD center's collaborative environment. His laboratory employs cutting-edge molecular, biochemical, and computational tools to investigate RNA-protein interactions and splicing mechanisms. The Center for Gene Regulation in Health and Disease provides infrastructure for interdisciplinary research through its CSU/Cleveland Clinic Joint Ph.D. Programs and shared instrumentation facilities.