معرفی
Gilberto Fisone is a Professor and Head of the Department of Neuroscience at Karolinska Institutet. His research focuses on understanding the molecular and cellular mechanisms underlying neurodegenerative and neuropsychiatric disorders, particularly Parkinson’s disease (PD), with an emphasis on motor and non-motor symptoms and complications of dopamine replacement therapies. He holds academic positions including Professor of Neuroscience (2006–present) and Head of Department (2021–present).
Education: BSc from the University of Pavia (1982), Ph.D. from Stockholm University (1990), followed by postdoctoral training at The Rockefeller University (1991–1995). His career includes roles as Assistant and Associate Professor at Karolinska Institutet before becoming a Full Professor in 2006.
Research interests include:
- Mechanisms of L-DOPA-induced dyskinesia and psychiatric complications (e.g., addiction-like behaviors).
- Non-motor symptoms in PD, such as sleep disorders, anxiety, and circadian rhythm disruptions.
- Role of signal transduction pathways (cAMP, ERK, mTOR) in PD pathology.
Notable contributions include developing mouse models to study PD comorbidities and identifying autophagy as a therapeutic target for dyskinesia. His work has been supported by grants, including the Neurophage project exploring non-invasive neural stimulation.
Awards and roles: Member of Academia Europaea (2022–present), Secretary of the International Basal Ganglia Society, and leadership in international collaborations. His lab, 'Molecular and Circuit Neuropharmacology', investigates neural circuits and pharmacological interventions in neurodegenerative diseases.
