معرفی
Giampaolo Barone is a Full Professor (CHEM-03/A) at the University of Palermo within the Biological, Chemical and Pharmaceutical Sciences and Technologies school. His office is located at Viale delle Scienze, Building 17, 90128 Palermo, where he holds office hours on Wednesdays from 3:00 PM to 5:00 PM. His teaching responsibilities include General Chemistry (3 CFU) for Prevention Techniques in the Environment and Workplace, General and Inorganic Chemistry (8 CFU) for Pharmaceutical Chemistry and Technology, Inorganic Chemistry (6 CFU) for Chemistry, Inorganic Chemistry with Laboratory (10 CFU) for Chemistry, and Chemistry for Elementary and Kindergarten Schools (4 CFU).
Professor Barone's research focuses on bioinorganic chemistry, particularly the interaction of metal complexes with DNA structures. His work spans from fundamental studies of DNA binding mechanisms to applications in anticancer drug development. He employs both experimental techniques (spectroscopy, fluorescence titration) and computational methods to investigate how metal complexes interact with DNA, especially G-quadruplex structures that play crucial roles in gene regulation and cancer pathways. His research demonstrates consistent productivity with numerous publications each year across high-impact journals in chemistry, biochemistry, and pharmacology.
Analysis of his recent publications (2024-2025) reveals several key research trends: 1) Development of metal-based compounds (particularly copper, nickel, and ruthenium complexes) as anticancer agents targeting DNA structures; 2) Investigation of G-quadruplex DNA stabilization and its implications for oncogene regulation; 3) Creation of novel sensors for environmental and biological applications; 4) Exploration of marine biomolecules for therapeutic uses; and 5) Methodological improvements in measuring DNA binding constants.
Throughout his career, Professor Barone has supervised numerous graduate students across Chemistry, Pharmaceutical Chemistry, and Biological Sciences programs. His edited theses cover diverse topics including DNA-metal complex interactions, spectroscopic studies, synthesis of bioactive compounds, and applications in medical diagnostics. His research has significant implications for developing new anticancer therapies, environmental monitoring tools, and fundamental understanding of biomolecular interactions.