George F. Rich

George F. Rich is the Harrison Medical Teaching Professor and Chair of the Department of Anesthesiology at the University of Virginia School of Medicine. He also holds a professorship in the Department of Biomedical Engineering, reflecting his interdisciplinary expertise. His clinical and research leadership is central to the department's mission in education, patient care, and research.

Dr. Rich earned his B.S. in Mechanical Engineering, M.D., and Ph.D. in Bioengineering, all from the University of Utah. This unique combination of training underpins his research at the intersection of engineering and medicine.

His research focuses on cardiovascular engineering, particularly the role of endothelial pathways in vascular regulation. Key areas include the nitric oxide/guanylate cyclase system, inhaled nitric oxide therapy for pulmonary hypertension, and vascular dysfunction in sepsis. Using chronic hypoxia rat models and isolated organ systems, his lab investigates both acute and long-term vascular responses with direct clinical relevance.

His recent publications reveal a consistent focus on nitric oxide signaling, pulmonary vasoconstriction, and inflammatory modulation in animal models. The work spans physiology, pharmacology, and critical care, demonstrating translational impact.

• Effects of anesthesia on endothelium and vascular smooth muscle

Dr. Rich leads significant research initiatives funded by grants related to vascular function and anesthesia. While specific students are not listed, his role as a professor and research leader implies active mentorship of trainees and junior scientists. He also contributes to medical education as a named teaching professor.

His laboratory work involves integrated physiological models including isolated lung and kidney preparations, complemented by molecular techniques such as western blotting, light microscopy, and radioimmunoassays, forming a comprehensive approach to studying vascular tone and endothelial health.