معرفی
Gaétan THIBAULT is a Professor in the Department of Medicine at the University of Montreal's Faculty of Medicine. His research focuses on integrin signaling and its role in cardiac hypertrophy, particularly examining how integrins mediate cell-matrix interactions in cardiovascular cells under vasoactive agents like angiotensin II and endothelin-1. His work aims to uncover therapeutic targets for cardiac fibrosis and hypertrophy.
Research Projects:
- 2008-2011: MODULATION DE LA FIBROSE CARDIAQUE PAR LES INTERACTIONS LEUCOCYTE-FIBROBLASTE (Principal Investigator)
Supervised Students (Master's):
- Nadia Oualha (2014): Empéripolèse des cellules de lymphomes humains Ramos par les fibroblastes
- François Hudon-David (2007): Expression de la protéine Thy-1 sur les fibroblastes cardiaques et lors de la fibrose cardiaque
- Julie Pepin (2004): TGF-β₁ effects on fibroblast-vascular smooth muscle cell interactions
- Marie-Josée Lacombe (2002): Functional analysis of RGD integrins
- Émilie Viel (2002): Regulation of RGD integrins in vascular smooth muscle cells
- Sandrine Joly (2001): RGD integrins in cardiac cells
- Alexandre Lacasse (1998): Natriuretic peptides in cardiac fibroblast proliferation
- Huu Bach Nguyen (1997): Natriuretic peptides in volume-overload cardiac hypertrophy
- Lucie Canaff (1996): Calcium-binding site role in pro-ANF secretion
His research combines biochemistry, molecular biology, and cardiology to elucidate cellular mechanisms in cardiovascular pathologies such as hypertension and heart failure. His methods emphasize fundamental investigation of cell signaling pathways and extracellular matrix interactions.
