Ganes C. Sen

Ganes C. Sen, PhD, holds the title of Professor in the Departments of Molecular Medicine, Biochemistry, and Pathology at the School of Medicine, Case Western Reserve University. He also serves as a Member of the Molecular Oncology Program at the Case Comprehensive Cancer Center and holds the Thomas Lord Endowed Chair in Molecular Biology at the Lerner Research Institute, Cleveland Clinic. Additionally, he is Staff in the Department of Inflammation and Immunity at the Lerner Research Institute.

His research focuses on mammalian gene expression related to interferon and angiotensin-converting enzyme, with a primary emphasis on understanding viral infection responses in mammals. Key areas include the mechanism of interferon (IFN) induction, Toll-like receptor 3 (TLR3) signaling, RIG-I-like helicase receptor pathways, and the antiviral functions of IFIT proteins. Recent studies involve IFIT gene knockout mouse models to elucidate virus-specific inhibition patterns and the dual role of IRF-3 in both IFN induction and apoptosis via Bax mitochondrial transport.

External Appointments include roles at the Lerner Research Institute, Cleveland Clinic. No specific grants or advising details are listed in the provided text.