معرفی
Dr. Frederick Sheedy is an Associate Professor at the School of Biochemistry & Immunology, Trinity College Dublin, Ireland. He leads research on macrophage function in health and disease, with a focus on innate immune training, microRNA regulation, and immunometabolism. His work bridges host-pathogen interactions (notably tuberculosis) and metabolic-inflammatory crosstalk in conditions like atherosclerosis and obesity.
- Established independent research group at TCD
- Key contributions to microRNA-21 and microRNA-33 roles in inflammation
- Collaborations with local food companies on β-glucan-induced immune training
- Previously held postdoctoral fellowship at NYU
Dr. Sheedy’s research portfolio includes 15+ peer-reviewed publications in high-impact journals like Nature Immunology, Cell Reports, and Nature Communications. His work reveals how metabolic pathways regulate antimicrobial responses, with implications for infectious diseases, cardiovascular disorders, and nutritional immunology. Recent studies investigate β-glucan and Trained Immunity for infection resistance.
- Trained Immunity
- MicroRNA-21/33
- Tuberculosis Immunology
- Metabolic Inflammation
- Fungal Immunomodulation
- Host-Pathogen Metabolism
Scientific accolades include the Trinity Innovation Award (2020), Provost PhD Award (2020), and Researcher of the Year at Trinity Institute of Molecular Medicine (2013). His funding history spans prestigious grants from Science Foundation Ireland, Irish Research Council, Wellcome Trust, and Enterprise Ireland for studies on innate immune memory, metabolic disease, and antimicrobial immunity.
- Trinity Innovation Award - Industry Engagement 2020
- Provost PhD Award 2020
- Researcher of the Year, TCD 2013
- Senior Research Fellow, TCD 2014
Dr. Sheedy’s work has been recognized through collaborations with local food industry partners and invitations to speak at international symposia. His research emphasizes translational immunology, linking nutritional interventions to immune modulation in both infectious and non-communicable diseases.
