Frank Tacke

Professor Frank Tacke, Ph.D. is a Professor at Charité - Universitätsmedizin Berlin, based at Campus Charité Mitte within the Medical Clinic with a Focus on Hepatology and Gastroenterology (CCM). His research primarily focuses on liver immunology, particularly the role of macrophages and monocytes in liver disease pathogenesis and progression.

Dr. Tacke's research interests span several critical areas in hepatology:

• Hepatic macrophage function in metabolic liver disease
• Gut-liver axis communication and its impact on liver immunity
• Monocyte and macrophage subpopulations in liver fibrosis
• Immunological mechanisms in non-alcoholic fatty liver disease (NAFLD) and metabolic dysfunction-associated steatotic liver disease (MASLD)
• Therapeutic targeting of immune cells in liver disease
• Role of platelets and innate immunity in liver fibrosis

His recent publications demonstrate a strong focus on translational research, with particular emphasis on understanding the immunological mechanisms underlying metabolic liver diseases and developing targeted therapeutic approaches. His work bridges basic immunological research with clinical applications in hepatology.

Dr. Tacke has received significant research funding through various mechanisms including:

• Transregio Collaborative Research Centers (TRR 412)
• Emmy Noether Junior Research Groups
• Material grants for specific research projects
• Clinical studies funding

He serves as a speaker for TRR 412, a major collaborative research center focused on metabolic dysfunction-associated steatotic liver disease, indicating his leadership position in this field. He also manages several sub-projects within collaborative research frameworks, demonstrating his expertise in specific aspects of liver immunology.