Francis G. Spinale

Francis G. Spinale is a Professor in the Department of Cell Biology & Anatomy at the University of South Carolina School of Medicine, with concurrent appointments at the Medical University of South Carolina (MUSC) in Surgery, Physiology, Anesthesiology, and Pediatrics since 1996. He serves as Director of the Cardiovascular Translational Research Center and practices as a physician at the WJB Dorn VA Medical Center.

His academic credentials include:

• Ph.D. in Pathology from the Medical University of South Carolina (1985)
• M.D. from the Medical University of South Carolina (1993)

Dr. Spinale's research fundamentally centers on cardiovascular remodeling mechanisms in heart failure, with particular emphasis on matrix metalloproteinases and their tissue inhibitors. His work bridges molecular biology, translational engineering, and clinical applications, pioneering biomaterial-based interventions like biocomposite injections and bioresponsive hydrogels to modulate post-infarction remodeling and cardiac function. This interdisciplinary approach integrates cardiovascular physiology with biomedical engineering to develop novel therapeutic strategies.

Analysis of his 2014 publications reveals a cohesive research trajectory targeting extracellular matrix dynamics in heart disease, with consistent focus on left ventricular remodeling after myocardial infarction and pressure overload. His studies strategically combine molecular manipulation of matrix metalloproteinases with advanced biomaterial delivery systems, establishing a translational pipeline from bench to bedside for heart failure therapeutics.

His scientific recognition includes:

• Breakthrough Leadership in Research Award from the University of South Carolina (2014)
• Fellowship in the American Heart Association
• Fellowship in the American College of Cardiology

Dr. Spinale has secured significant research funding including an NIH Small Business Technology Transfer grant for cardiac microdialysis/microfluidics systems, holds multiple patents, and maintains over 400 peer-reviewed publications. He serves on seven editorial boards and consults for pharmaceutical/biotechnology firms while mentoring researchers through his extensive publication record and leadership roles.

He directs the Cardiovascular Translational Research Center, driving collaborations between the School of Medicine and VA systems to advance cardiac research through integrated basic science and clinical investigations.