Francesco Iorio

Francesco Iorio is a Research Group Leader in Computational Biology at Human Technopole (Milan, Italy), leading research in computational cancer pharmacogenomics and therapeutic target discovery. He holds a PhD from the University of Salerno and TIGEM (Naples), focusing on computational methods for drug discovery. Previously, he was a Senior Bioinformatician at EBI, leading CRISPR-Cas9 screen analyses across cancer cell lines to identify synthetic lethalities and therapeutic targets. He led the Cancer Dependency Map Analytics team at Wellcome Sanger Institute, developing algorithms for integrating large-scale cancer datasets. Since 2019, he serves as a Scientific Advisor to the Cancer Research Horizon–AstraZeneca Functional Genomics Centre.

His research integrates computational methods with experimental data to uncover cancer dependencies, drug mechanisms, and biomarkers. Key contributions include tools like CRISPRcleanR for bias correction in CRISPR screens, and CELLector for selecting cancer cell line models. His work spans pharmacogenomics, functional genomics, and CRISPR technologies, with a focus on translating findings into clinical applications.

Publications highlight advancements in CRISPR screen analysis, cancer dependency mapping, and drug repositioning. Current projects aim to advance precision medicine through computational frameworks for understanding tumor heterogeneity and therapeutic vulnerabilities.