معرفی
Franca Fraternali is a Professor at King's College London, leading research in protein interactions and computational structural biology. Her work focuses on understanding molecular mechanisms of neurodegenerative diseases, cancer-related kinases, and genetic variations' impact on protein stability. She has contributed to over 116 research outputs and led/co-investigated 49 projects, including initiatives funded by BHF, BBSRC, and the Royal Society of Chemistry.
Her research interests include bioinformatics analysis of protein interactions, molecular simulations, and developing tools to assess genetic variants' effects. Notable projects include studying titin variants in cardiomyopathy and antibiotic resistance mechanisms in bacteria. She collaborates widely across disciplines, contributing to UN Sustainable Development Goals through biomedical research advancements.
Recent publications highlight work on NKT cell regulation in intestinal homeostasis, endothelial cell permeability sensors, and B cell dysregulation in melanoma. Fraternali's lab develops computational methods for variant impact assessment, exemplified by tools like ELVIS. She actively engages in academic leadership, mentoring 17 supervised works and contributing to King's College's structural biology infrastructure through cryo-electron microscopy projects.
