معرفی
Felipe Diaz-Griffero is a Professor in the Department of Microbiology & Immunology at Albert Einstein College of Medicine, holding the Elsie Wachtel Faculty Scholar title. His research focuses on understanding how host restriction factors block HIV-1 replication, particularly mechanisms involving capsid uncoating, nuclear import, and intranuclear events. His lab employs in vitro and in vivo models to study viral restriction factors like TRIM5α and MxB, as well as nuclear transport proteins such as TNPO3.
Research interests include HIV-1 life cycle dynamics, innate immunity, and antiviral drug discovery. Key projects explore how restriction factors accelerate HIV-1 uncoating, mechanisms of capsid nuclear import, and roles of proteins like CPSF6 in viral integration. His work also investigates elite controllers—HIV-1-infected individuals with natural viral suppression—to identify novel restriction pathways.
Selected publications highlight contributions to HIV capsid stabilization, SAMHD1 antiviral activity, and TNPO3-dependent nuclear import. Diaz-Griffero has been recognized as an Elsie Wachtel Faculty Scholar. His lab collaborates broadly, advancing understanding of HIV pathogenesis and therapeutic targets.
