Fabio Catalano

Fabio Catalano is a Researcher at Erasmus University Medical Center in the Faculty of Medicine, specializing in pediatric gene therapy research. His work focuses on developing novel therapeutic approaches for rare genetic disorders, particularly Mucopolysaccharidosis Type II (Hunter Syndrome) and Pompe Disease.

Dr. Catalano's research interests span multiple critical areas in genetic medicine:

• Lentiviral gene therapy vectors for rare diseases
• Enzyme replacement strategies using tagged proteins
• Overcoming immune responses in gene therapy
• Correction of peripheral and central nervous system pathology in lysosomal storage disorders
• Development of clinically relevant dosing regimens
• Prevention of antibody formation against therapeutic enzymes

His recent publications demonstrate significant progress in developing gene therapy approaches that prevent life-threatening pathology in animal models of rare diseases. Notably, his work on IGF2-tagging of therapeutic enzymes has shown promise in achieving full correction of disease phenotypes at clinically feasible doses, with several publications being referenced in patents and picked up by news outlets.

Dr. Catalano has established a strong collaborative network within Erasmus MC, working with experts in pediatric genetics, gene therapy, and lysosomal storage disorders. His research has generated substantial interest in the scientific community as evidenced by citations, Mendeley readership, and social media mentions.