معرفی
Eunus S. Ali is an Assistant Professor in the Department of Toxicology and Cancer Biology at the University of Kentucky College of Medicine. He leads the EAL-METABO Lab, focusing on cancer metabolism, neuroimmunometabolism, and metabolic regulation in malignant cells. His work emphasizes therapeutic strategies targeting metabolic pathways to combat diseases like glioblastoma and prostate cancer. Ali is a member of the Markey Cancer Center and the Center for Cancer and Metabolism.
Education: PhD from Flinders University (supervised by Dr. Greg Barritt), MS from Stockholm University (Dr. Göran Widmalm), and postdoctoral training at Northwestern University (Dr. Issam Ben-Sahra).
Research interests center on how signaling pathways and metabolic processes drive cancer progression. His lab investigates nucleotide metabolism, drug resistance mechanisms, and calcium signaling's role in cancer. Recent work highlights targeting metabolic enzymes (e.g., PHGDH, RRM2) and purine biosynthesis to overcome chemoresistance.
Publications (2021–2025) focus on cancer metabolism, drug development, and metabolic pathways in tumors. Key topics include TRPM2 channels, mTOR signaling, and combination therapies targeting metabolic vulnerabilities.
Labs/Teams: Principal Investigator of the EAL-METABO Lab and collaborator with the Center for Cancer and Metabolism. Research integrates molecular biology, biochemistry, and pharmacology to advance oncology therapeutics.
