معرفی
Erol Fikrig is the Waldemar Von Zedtwitz Professor of Medicine (Infectious Diseases) and Professor of Epidemiology (Microbial Diseases) and Microbial Pathogenesis at Yale School of Medicine. He serves as Section Chief of Infectious Diseases and is affiliated with the Yale Institute for Global Health and the Fikrig Lab.
- Yale Combined Program in the Biological and Biomedical Sciences
- Yale-UPR Integrated HIV Basic and Clinical Sciences Initiative
Education:
- MD, Cornell University (1985)
- Residency, Vanderbilt University Hospital (1988)
- Fellowship, Yale University School of Medicine (1991)
Research Interests
Dr. Fikrig investigates molecular interactions between pathogens (Borrelia burgdorferi, Flaviviruses, Plasmodium) and their vectors (ticks, mosquitoes), focusing on:
- Mechanisms of immunity evasion in vector-borne diseases
- mRNA vaccine development targeting vector salivary proteins
- Pathogen transmission dynamics at the vector-host interface
- Immunomodulation by arthropod saliva
- Tick and mosquito genetic targets for disease prevention
- Host-pathogen-vector triangular interactions
Publication Trends
Recent work emphasizes:
- mRNA vaccines for tick-borne diseases (Lyme, babesiosis)
- Salivary biomarkers of Plasmodium exposure
- Tick protein disulfide isomerases in Borrelia colonization
- AgTRIO and mosGILT proteins in mosquito biology
- Immune checkpoint targeting by mosquito factors
- Epidemiological modeling of vector-pathogen systems
Scientific Honors
- National Academy of Medicine (2024)
- NIH Merit Award
- Howard Hughes Medical Institute Investigator
- Pew Scholar in Biomedical Sciences
- Infectious Disease Society of America Vaccine Development Award
Collaborative Networks
Key collaborations include:
- Yale School of Public Health researchers
- Johns Hopkins Malaria Research Group
- National Institutes of Health Tick-Borne Disease Working Group
- European Tick Vaccine Consortium
- Center for Infection and Immunity
- Yale-UPR HIV Research Initiative
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