معرفی
Enzo Alessio is a Full Professor at the Department of Chemical and Pharmaceutical Sciences, University of Trieste. His research spans coordination chemistry, organometallic chemistry, and medicinal inorganic chemistry, focusing on developing metal-based therapeutics and supramolecular assemblies for photocatalysis. He leads a collaborative research group involving PhD and master’s students, with partnerships across Italian and international institutions, including the University of Zurich and ELETTRA Sincrotrone Trieste.
His work in medicinal inorganic chemistry pioneered the development of NAMI-A, a ruthenium anticancer complex tested in Phase I/II clinical trials for non-small cell lung carcinoma. This research combines photodynamic therapy (PDT) with metal cytotoxicity to create theranostic agents for fluorescence and radio-imaging. Collaborations with Prof. Gianni Sava and Dr. Alberta Bergamo extend his impact.
Scientific Leadership:
- Editorial Board member of Journal of Inorganic Biochemistry and European Journal of Inorganic Chemistry
- Coordinator for PhD Cycles XXVII-XXXVIII in Chemistry
- Supervised over 35 master’s students and 3 PhD candidates
Research Trends: His publications (169 peer-reviewed, 10 patents) highlight Ru(II) and Re(I) complexes for molecular imaging and photocatalysis, emphasizing water-soluble metallodrugs and ligand design for anticancer applications. Clinical studies with NAMI-A mark a milestone as the first ruthenium compound tested in humans.
