معرفی
Dr. Ellen F. Foxman is an Associate Professor in both the Department of Laboratory Medicine and the Department of Immunobiology at Yale School of Medicine. She is a physician-scientist specializing in clinical pathology and the host immune response to respiratory viral infections. Her research is centered on understanding innate antiviral defense mechanisms in the human airway epithelium and how environmental factors such as temperature and oxidative stress modulate these defenses.
- Department of Laboratory Medicine, Yale School of Medicine
- Department of Immunobiology, Yale School of Medicine
- Foxman Lab, Yale University
- Human and Translational Immunology Program, Yale
- Center for Infection and Immunity, Yale
- Yale Combined Program in the Biological and Biomedical Sciences (BBS)
Dr. Foxman earned her PhD and MD from Stanford University School of Medicine, followed by residency training in Clinical Pathology at Brigham and Women's Hospital, Harvard Medical School. She conducted postdoctoral research in the lab of Dr. Akiko Iwasaki at Yale before launching her independent research group in 2016.
Her research focuses on the molecular mechanisms of innate immunity in the respiratory tract. Key areas include:
- How cool ambient temperatures suppress antiviral responses in nasal epithelial cells, increasing susceptibility to rhinovirus
- The role of oxidative stress and the NRF2 pathway in modulating antiviral signaling
- The phenomenon of viral interference, where infection with one virus (e.g., rhinovirus) can transiently protect against others (e.g., influenza, SARS-CoV-2) via interferon-mediated defenses
- Developing host-response-based biomarkers for diagnosing respiratory infections using clinical samples
Analysis of her recent publications reveals a strong focus on translational immunology, with an emphasis on nasal innate immunity, viral co-infections, interferon responses, and diagnostic applications. Her work bridges basic science and clinical medicine, often utilizing human samples and epithelial cell models.
Dr. Foxman has been recognized with several prestigious awards:
- 2021 Rita Allen Foundation Scholars Award
- 2021 ASCI Young Physician-Scientist Award
- 2018 Hartwell Foundation Individual Biomedical Research Award
- 2019 Levine Lab Laureate Award
- Yale -New Haven Health System Innovation Award (2022)
She has an active research program with consistent funding and collaborations across Yale. She mentors trainees and contributes to graduate education through the BBS program. While specific advisees are not listed, her lab is actively publishing with junior researchers. Her work has significant implications for understanding seasonal virus dynamics, improving diagnostics, and developing novel antiviral strategies.
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