معرفی
Elizabeth Topp is a Professor of Industrial and Physical Pharmacy and Professor of Chemical Engineering at Purdue University's College of Pharmacy. With expertise in protein stability and formulation, she leads research on chemical and physical degradation of protein drugs in amorphous solid states. Her work bridges pharmaceutical sciences and chemical engineering, focusing on innovative analytical techniques for biopharmaceutical development.
- BChE, 1979, The University of Delaware
- ME, 1984, The University of Pennsylvania
- PhD, 1986, The University of Michigan
Professor Topp's research centers on protein stability in solid dosage forms, with particular focus on chemical degradation reactions in amorphous solids. Her laboratory develops advanced techniques like solid-state hydrogen/deuterium exchange mass spectrometry (ssHDX-MS) to examine protein structure and excipient interactions. Current projects investigate deamidation mechanisms in antibodies, controlled release systems for immunomodulating peptides, and degradation pathways of small molecule pharmaceuticals. Her work provides critical insights for developing stable, effective biopharmaceutical products with extended shelf lives.
Analysis of Professor Topp's recent publications reveals a strong focus on advanced analytical techniques for protein characterization in solid states, particularly ssHDX-MS. Her research spans fundamental protein chemistry to practical formulation challenges, with emphasis on lyophilization, spray drying, and excipient effects. The publications demonstrate consistent innovation in probing protein-excipient interactions and developing predictive stability models for biopharmaceuticals.
- Notable publications in top journals including Journal of Pharmaceutical Sciences, Molecular Pharmaceutics, and Biophysical Journal
- Contributions to book chapters on lyophilization and mass spectrometric methods
Professor Topp advises numerous graduate students and postdoctoral researchers, with her laboratory consistently securing research funding from pharmaceutical industry partners and federal agencies. Her collaborative work spans multiple departments at Purdue, including Chemical Engineering and Pharmacy, and involves partnerships with industry leaders in biopharmaceutical development.
The Topp Laboratory maintains state-of-the-art facilities for protein formulation, lyophilization, and advanced analytical characterization. The research team employs diverse techniques including mass spectrometry, spectroscopy, and novel photolytic labeling methods to investigate protein behavior in solid states.
