Eduardo Rivera Mancilla

Eduardo Rivera Mancilla is a Researcher in the Department of Internal Medicine at Erasmus University Medical Center, specializing in migraine pathophysiology and transient receptor potential (TRP) channel research. His work bridges vascular biology and neuropharmacology with a particular focus on sex differences in pain mechanisms.

His research interests include:

• Migraine pathophysiology and treatment
• Transient Receptor Potential (TRP) channels (TRPM3, TRPA1, TRPV1)
• Calcitonin Gene-Related Peptide (CGRP) signaling
• Vascular biology in neurovascular disorders
• Sex differences in pain and vascular responses
• Hormonal influences on migraine

Recent publications demonstrate his focus on TRP channel functioning in vascular systems, particularly examining sex differences that could inform female-specific migraine therapies. His research shows strong collaboration with the MaassenVanDenBrink research group at Erasmus MC.

His scientific contributions include:

• Investigating TRPM3 as a therapeutic target for neurovascular disorders
• Elucidating CGRP-induced relaxation mechanisms in coronary arteries
• Analyzing TRP channel roles in dermal artery modulation
• Exploring prolactin and oxytocin as potential migraine treatment targets