Donghoon Yoon

Donghoon Yoon, PhD, serves as Associate Professor in the Department of Internal Med Myeloma Research at the College of Medicine, University of Arkansas for Medical Sciences, with a Cancer Biology research program focused on multiple myeloma pathophysiology and bone disease mechanisms.

Dr. Yoon's research interests include:

• Pathophysiology of multiple myeloma (MM) and malignant plasma cell proliferation
• Bone metabolism factors influencing MM growth and osteolytic lesions
• Early detection of MM-induced bone disease (MMBD) using collagen hybridizing peptide (CHP)
• Defining MMBD stages based on osteolysis process
• Development of Patient-Derived Xenograft (PDX) mouse models for MM, lymphoma, and non-small cell lung cancer
• Humanized mouse strain engineering for tumor engraftment

His 2021-2025 publications reveal a strong focus on myeloma bone disease modeling, with significant contributions in animal model development (including improved MM bone disease models and lymphoma models), collagen-binding therapeutics (NIPEP-OSS), and cross-disciplinary applications in biosensors and microneedle technology. The work demonstrates an interdisciplinary approach integrating cancer biology, bone metabolism, and translational engineering to advance early detection and therapeutic strategies.

No scientific awards were mentioned in the source documentation.

Dr. Yoon serves as Principal Investigator on an active Calcium & Bone Health Institute grant (2023-2028; AWD00055821) investigating Sigma Anti-Bonding Calcium roles in multiple myeloma and wound healing. While specific advisees aren't listed, his active PDX model development and grant leadership indicate ongoing mentorship of students and postdoctoral researchers in cancer biology and translational modeling.

His laboratory specializes in developing Patient-Derived Xenograft models using a proprietary humanized mouse strain, with current emphasis on characterizing MM-induced bone disease progression and therapeutic responses through collagen degradation imaging.