Dominic B. Fee

Dominic B. Fee, MD serves as Vice Chair and Professor in the Department of Neurology at the Medical College of Wisconsin, specializing in neuromuscular medicine with clinical expertise at Froedtert Hospital in Milwaukee. His practice focuses on complex neuromuscular disorders including ALS, myasthenia gravis, mitochondrial diseases, and peripheral neuropathies.

His educational foundation includes:

• Doctor of Medicine - University of Iowa College of Medicine (1996)
• Internship in Internal Medicine - Northwestern University (1996-1997)
• Residency in Neurology - University of Wisconsin Hospitals and Clinics (1997-2000)
• Fellowship in Neuromuscular Disease/Clinical Neurophysiology - University of Wisconsin Hospitals and Clinics (2000-2002)
• Fellowship in Neurogenetics - Cedars-Sinai Medical Center (2003-2004)

Dr. Fee's research centers on advancing ALS therapeutics through innovative clinical trial methodologies. He is a principal investigator in the landmark HEALEY ALS Platform Trial, which has evaluated multiple drug regimens including reldesemtiv, pridopidine, and zilucoplan. His work integrates electrodiagnostic medicine with translational neuroscience to develop targeted interventions for neuromuscular degeneration. Recent publications demonstrate expertise in adaptive trial design, biomarker validation, and neuroprotective strategies.

Analysis of his 12 most recent publications (2020-2025) reveals consistent leadership in ALS platform trials, with 10 of 12 articles directly related to the HEALEY trial's operational framework. His research spans pharmacological interventions, statistical innovations in trial design, and caregiver support systems, establishing him as a key contributor to both clinical neurology and trial methodology.

Dr. Fee holds board certifications in Neurology, Clinical Neurophysiology, Electrodiagnostic Medicine, and Neuromuscular Medicine. His clinical practice utilizes advanced diagnostic techniques including electromyography (EMG), nerve conduction studies (NCVs), and muscle biopsies across infant to senior patient populations.

As Vice Chair of Neurology, he directs significant research operations including multicenter trial coordination and clinical program development. His leadership in the HEALEY ALS Platform Trial represents major grant-funded collaboration across 50+ institutions, with emphasis on accelerating therapeutic development through adaptive statistical frameworks. He also contributes to caregiver support initiatives like the YCare protocol for youth caregivers in ALS.