معرفی
Dr. Dohun Pyeon is a Professor in the Department of Microbiology and Molecular Genetics at Michigan State University (MSU). His research focuses on HPV-associated cancers, particularly investigating virus-host interactions to develop preventive and therapeutic strategies. Prior to MSU, he held positions at the University of Colorado School of Medicine and completed postdoctoral training at Harvard Medical School, following his M.S. and Ph.D. from the University of Wisconsin-Madison.
Dr. Pyeon’s research highlights the role of chemokine CXCL14 in tumor suppression through immune cell recruitment and the mechanisms of APOBEC3A as a restriction factor against HPV infection. His lab explores novel immunotherapies targeting cervical and head/neck cancers, leveraging insights into CXCL14-mediated immune responses and epigenetic immune evasion by HPV.
Key findings include CXCL14’s ability to suppress tumor growth by enhancing MHC-I expression and CD8+ T-cell activity, and APOBEC3A’s role in HPV infection restriction and somatic mutagenesis in cancer progression. His work also reveals how HPV upregulates MARCHF8 to degrade tumor-suppressor proteins, enabling immune evasion.
Dr. Pyeon’s articles emphasize viral oncogenesis mechanisms, CRISPR-based screening for immune evasion pathways, and SARS-CoV-2 vaccine development using bacteriophage platforms. His interdisciplinary approach bridges virology, immunology, and cancer biology.
Labs/Teams: The Pyeon Lab at MSU focuses on translating molecular discoveries into clinical immunotherapies. Current projects include developing CXCL14-based therapies and studying APOBEC3A’s dual roles in HPV infection and cancer evolution.
