Diego Mastroeni

Diego Mastroeni is a Research Associate Professor at Arizona State University (ASU), affiliated with the ASU-Banner Neurodegenerative Disease Research Center and the Biodesign Institute. His work focuses on neurodegenerative diseases, particularly Alzheimer’s and Parkinson’s, with a strong emphasis on epigenetics, mitochondrial dysfunction, and microglial biology. He holds a PhD in Neuroscience from Maastricht University and conducted postdoctoral training at the Banner Sun Health Research Institute.

Research Interests:

• Epigenetic mechanisms in neurodegeneration
• Microglial and neuronal heterogeneity
• Single-cell transcriptomics
• Alzheimer’s disease biomarkers
• Age-related neurodegeneration

Key Projects:

• Ongoing Alzheimer’s Association grant (2018–2021): Investigating gender effects in Alzheimer’s cell populations
• NOMIS Foundation-funded project (2018–2023): Creating a public resource of brain cell RNA sequencing data
• EU JPND Research initiative (2017–2021): Targeting epigenetic dysregulation in Alzheimer’s

Publications: Over 40 peer-reviewed articles, including seminal work on DNA methylation in Alzheimer’s and laser capture microdissection techniques. Recent focus on microglial transcriptomics and novel therapeutic targets.

Teaching: Involvement in undergraduate research courses (e.g., BCH 392, BIO 495) emphasizing research techniques and honors thesis supervision.