معرفی
Derek S. Sieburth is an Associate Professor in the Department of Physiology & Neuroscience at the University of Southern California (USC). His research focuses on understanding signaling pathways that regulate neuronal function and stress responses in the nervous system, using Caenorhabditis elegans as a model organism. The Sieburth lab employs advanced techniques in behavioral analysis, genetics, cell biology, and in vivo imaging to study mechanisms of neurotransmitter and neuropeptide secretion, oxidative stress responses, and sphingolipid signaling in neurons.
Key research areas include molecular mechanisms of neuropeptide storage/secretion, oxidative stress effects on neurotransmission, and sphingolipid regulation of mitochondrial homeostasis. The lab’s work has implications for understanding human neuronal function and neurodegenerative diseases.
Recent publications highlight studies on hydrogen peroxide regulation of gut-derived neuropeptide secretion, electrical synapse coordination of rhythmic behaviors, and mitochondrial signaling pathways in stress responses. The lab collaborates with USC’s resources and maintains an active research program supported by grants from NIH, NINDS, and the American Heart Association.
