معرفی
Denis Jabaudon is a Professor and Group Leader in the Department of Basic Neurosciences at the Faculty of Medicine, University of Geneva, where he leads a research laboratory at Campus Biotech. His work focuses on the genetic and molecular mechanisms governing cortical neuron circuit assembly during development.
His research interests include developmental neurobiology, neuronal circuit formation, gene expression dynamics in neural progenitors and postmitotic neurons, thalamocortical connectivity, and neural plasticity. He investigates how intrinsic genetic programs and sensory experience interact to determine neuronal identity and circuit function. His lab employs techniques such as in vivo electroporation, transgenic mouse models, single-cell RNA sequencing, and electrophysiology.
The most recent publications highlight a strong trend in understanding the temporal patterning of neural progenitors and how this influences the sequential generation of diverse neuronal subtypes. His work demonstrates that molecular birthmarks in progenitors are transmitted to daughter neurons, which then undergo activity-dependent refinement. This research bridges developmental biology, epigenetics, and systems neuroscience, with implications for brain repair and reprogramming.
Scientific Awards and Funding:
- Swiss National Science Foundation Grant (PP00P3-123447)
- Velux Foundation Funding
- 3R Foundation Funding
- Brain and Behavior Research Foundation Funding
- Joint Leenaards Foundation for Scientific Research Award
Denis Jabaudon actively mentors a team of early-career researchers. His lab includes scientific collaborators such as Riccardo Bocchi and Sabine Fièvre, postdoctoral researchers like Awais Javed and Sergi Roig Puiggros, and graduate students including Eline Balavoine, Natalia Baumann, and Moein Sarhadi. His research has been supported by multiple competitive grants, indicating sustained funding and scientific impact. The lab’s work contributes significantly to understanding the fundamental principles of brain development and plasticity.
Laboratory and Team: The Jabaudon lab is based at Campus Biotech in Geneva and comprises a multidisciplinary team of scientific collaborators, postdoctoral fellows, graduate students, and technical staff, working collaboratively on projects related to neocortical development and circuit assembly.
