David X Zhang

David X. Zhang is an Associate Professor in the Department of Pharmacology and Toxicology at the Medical College of Wisconsin. His research focuses on understanding vascular signaling mechanisms, particularly the role of TRP channels in regulating blood vessel reactivity and homeostasis in diseases such as coronary artery disease (CAD), hypertension, and diabetes. His work integrates cellular, molecular, and physiological approaches to investigate endothelial and smooth muscle cell interactions.

Education: PhD in Pharmacology and Toxicology from the Medical College of Wisconsin (2003).

Research emphasizes TRPV4 channels' mediation of vasodilator factors (e.g., H2O2 in CAD) and smooth muscle K+ channel function. Studies utilize human tissue and animal models, employing techniques like patch clamping, Ca²⁺ imaging, and in vivo assays. Key findings include TRPV4's role in flow-induced vasodilation and H2O2's significance in CAD-affected vessels.

Publications span over two decades, addressing TRPV4 structure, NADPH oxidase inhibition, and viral-induced endothelial dysfunction. Collaborations include investigations into Rap1's role in endothelial inflammation and atherosclerosis progression.

Labs and teams focus on translational cardiovascular research, with projects exploring therapeutic targets for vascular pathologies and mechanisms underlying endothelial dysfunction in disease states.