معرفی
David Sanford is a Research Assistant Professor in the Department of Developmental, Molecular and Chemical Biology at Tufts University School of Medicine. His research focuses on analytical biochemistry and the application of physical and biological assays in drug discovery for type 2 diabetes, cancer, and cardiovascular disease.
Education:
- Doctor of Philosophy, University of Rochester, 1986
- Master of Science, University of Rochester, 1982
- Bachelor of Science, Purdue University, 1979
His primary research interests include analytical biochemistry, enzyme inhibition strategies, and developing therapeutic approaches for metabolic disorders and cancer. Specific focus areas encompass dipeptidyl peptidases (DPP IV, 8, 9), proteasome inhibitors, and peptide therapeutic stabilization. His work integrates high-throughput screening methodologies and biochemical assays to evaluate drug candidates.
His publications demonstrate consistent focus on protease inhibitors, boronic acid chemistry, and enzyme kinetics. Recent work emphasizes pyroptosis mechanisms and superfamily-wide enzyme profiling, while earlier contributions include fundamental studies on viral DNA binding and mitochondrial ferritin. The research consistently bridges medicinal chemistry with therapeutic applications in metabolic and oncological diseases.
