David R. Ghasemi

David R. Ghasemi is a researcher affiliated with the University of Hamburg's Faculty of Medicine, specifically within the Department of Pediatric Hematology and Oncology at the Center for Obstetrics and Pediatrics at the University Medical Center Hamburg-Eppendorf (UKE). His work focuses on pediatric oncology, particularly neuro-oncological malignancies such as medulloblastoma and ependymoma. Dr. Ghasemi’s research emphasizes molecular mechanisms underlying tumor development, genomic instability, and the identification of biomarkers for diagnosis and prognosis. He has contributed to international clinical trials (e.g., BIOMECA) and collaborates on projects involving multi-omics profiling, single-cell analysis, and functional genomics.

His expertise spans pediatric hematology/oncology, with a strong emphasis on tumor heterogeneity, fusion oncogenes (e.g., ZFTA-RELA, C11orf95), and the developmental origins of cancers. Key contributions include risk stratification in supratentorial ependymomas, understanding medulloblastoma subtypes (e.g., MBEN), and exploring therapeutic targets for aggressive tumors like MYCN-amplified spinal ependymoma. Dr. Ghasemi’s work bridges basic science and clinical applications, aiming to improve outcomes through precision medicine approaches.

Recent publications highlight advancements in tumor antigen mapping for immunotherapy, genomic profiling of chromothriptic tumors, and the developmental basis of SHH-driven medulloblastoma heterogeneity. His interdisciplinary collaborations span molecular biology, computational biology, and clinical oncology, contributing to both foundational knowledge and translational research in pediatric cancers.