David Pladevall Morera

David Pladevall Morera is a Researcher at the Department of Biomedical Sciences, reNEW, working in the Zylicz Lab at the University of Copenhagen. His research focuses on genome stability, DNA repair mechanisms, and the role of various proteins in maintaining chromosomal integrity.

His primary research interests include:

• Genome stability and DNA repair mechanisms
• Chromosomal fragile sites and their role in disease
• ATRX protein function in cancer and development
• Molecular mechanisms of chromosomal instability

Dr. Pladevall Morera's recent publications demonstrate significant contributions to understanding how DNA repair proteins maintain genome integrity and how their dysfunction leads to cancer. His work spans multiple model systems and employs diverse techniques including molecular biology, cell biology, and proteomics. He has made important contributions to understanding the role of ATRX in genome stability, the function of PICH in chromosome segregation, and the mechanisms underlying chromosomal fragile sites. His research shows a consistent focus on how defects in DNA repair pathways contribute to cancer development and progression.

His notable scientific contributions include:

• Elucidating the role of SLX4IP in common fragile site stability and DNA interstrand crosslink repair
• Investigating how PICH deficiency affects cancer progression
• Characterizing ATRX-deficient glioma cells and their therapeutic vulnerabilities
• Exploring chromatin dynamics as sensors of metabolic changes during development

Dr. Pladevall Morera collaborates extensively with researchers across the University of Copenhagen and internationally, particularly with the Hickson Lab, contributing to a vibrant research environment focused on understanding fundamental mechanisms of genome maintenance. His work bridges basic molecular mechanisms with potential clinical applications in cancer therapy.