David McDonald

Dr. David McDonald is a researcher at Newcastle University with a focus on immunology, mitochondrial dysfunction, and medical imaging techniques. His work spans collaborations with multiple disciplines, including studies on T regulatory cells in aging, immune dysregulation in autoimmune diseases, and mitochondrial anomalies in neurodegenerative and metabolic disorders.

• Immunology research includes T regulatory cell dynamics in psoriatic arthritis and rheumatoid arthritis, as well as dendritic cell subsets in synovial tissue.
• Mitochondrial studies explore respiratory chain defects in osteoblasts, Parkinson’s disease neuronal dysfunction, and DNA maintenance disorders.
• Medical imaging involves high-dimensional profiling via imaging mass cytometry for muscle degeneration, tumor modeling, and tissue analysis.
• Microbiome investigations examine gut metabolomes in preterm infants and their implications for disease modeling.

His publications reflect interdisciplinary applications of computational frameworks (e.g., OPTIMAL for imaging mass cytometry), single-cell analysis, and translational oncology in leukemia and glioblastoma research.