معرفی
David Knapp is a Principal Researcher at the Institute for Research in Immunology and Cancer (IRIC) within the University of Montreal. His research focuses on understanding the molecular basis of cell identity through single-cell analysis and synthetic genetic circuits, with applications in regenerative medicine and cancer therapy. Previously, he completed his PhD in Experimental Medicine at the University of British Columbia and a postdoctoral fellowship at the University of Oxford.
- Academic Role: Researcher, Department of Pathology and Cell Biology
- Research Unit: Cellular Engineering Research Unit
- Contact: david.knapp@umontreal.ca
His work explores the attractor state model of cell identity, investigating transitions between stable molecular states regulated by genetic networks. This research has implications for cell reprogramming, oncogenesis, and therapeutic target identification. He employs technologies like single-cell sequencing and synthetic biology to manipulate and analyze cell fate.
Recent publications highlight his expertise in hematopoietic stem cell dynamics, CRISPR optimization, and immune cell engineering. Articles span topics from Waddington-like landscapes to Cas9 guide RNA expression systems, reflecting his interdisciplinary approach.
Scientific Awards and Scholarships:
- SEDA Learning Support Award (2019)
- CIHR Postdoctoral Fellowship (2016–2019)
- CIHR Canada Graduate Scholarship - Master’s (2011–2012)
- CIHR Transplantation Research Scholarship (2010–2011)
David Knapp's research has been supported by grants from Canadian Institutes of Health Research (CIHR) and other national funding bodies. His laboratory at IRIC investigates molecular determinants of cell identity and collaborates with teams studying hematopoiesis, cancer signaling, and immunotherapies.
