معرفی
David I. Yule, Ph.D., is a Professor at the University of Rochester School of Medicine and Dentistry, holding dual appointments in the Department of Pharmacology and Physiology and the Department of Medicine, Gastroenterology/Hepatology. His research focuses on intracellular calcium signaling in exocrine cells, particularly pancreatic acinar cells and salivary gland cells, investigating how IP3 receptors and ryanodine receptors regulate fluid secretion, enzyme release, and pathophysiological responses in diseases like acute pancreatitis and Sjögren's Syndrome.
- Ph.D., University of Liverpool (1989)
- B.S., Portsmouth Polytechnic (1985)
- Postdoctoral work: MRC Secretory Control Group, University of Liverpool and University of Michigan
Yule's lab employs high-speed confocal microscopy, antisense technology, and fluorescence imaging to dissect agonist-specific signaling pathways and calcium release site organization. Current projects include studying IP3 receptor phosphorylation, genetic defects in calcium signaling linked to dry mouth diseases, and mitochondrial interactions in calcium dynamics.
His recent 15 most influential publications span topics from IP3R isoform regulation in gluconeogenesis to calcium oscillation modeling and Bcl-2 family modulation of apoptotic signaling. Collaborative work with institutions like Stanford and KU Leuven has produced key insights into organellar calcium channels.
- Recipient of the Louis C. Lasagna Professorship in Experimental Therapeutics (2016)
- Awarded with the 2016 Convocation Award at University of Rochester
As mentor, Yule supervises graduate students in multidisciplinary research, including projects on radiation-induced salivary dysfunction (Amanda Wahl, NIH F31 awardee) and mitochondrial Ca²⁺ handling. His lab maintains a 3D computational modeling partnership with J. Sneyd to integrate experimental data with theoretical frameworks.
