David Horn

David Horn is a Professor in Biological Chemistry and Drug Discovery at the University of Dundee. His research focuses on understanding the mechanisms of gene regulation in African trypanosomes, particularly regarding antigenic variation and drug resistance. He leads projects such as 'Decoding Mechanisms of gene regulation in African Trypanosomes' and collaborates on drug discovery initiatives like the 'Wellcome Centre for Anti-Infectives Research.'

• Key areas: Trypanosoma biology, drug development, parasitology
• Contributions: Over 140 research outputs, including studies on benzoxaboroles and post-transcriptional controls

Research interests center on trypanosome biology, with emphasis on molecular mechanisms underlying pathogenesis and drug resistance. His work integrates genomics, proteomics, and machine learning to decode complex biological processes.

Recent articles highlight advancements in machine learning applications for gene expression analysis and benzoxaborole-based antiparasitics. Awards include Fellow of the Academy of Medical Sciences (2025) for contributions to combating neglected tropical diseases.

Advises on drug target deconvolution projects and supervises research on trypanosome metabolism and antigenic variation. Collaborates internationally, with projects funded by the Medical Research Council and Wellcome Trust.