معرفی
David Corcoran is an Assistant Professor in the Department of Genetics at the University of North Carolina at Chapel Hill and Director of the LCCC Bioinformatics Core Facility. His research focuses on bioinformatics and computational biology, with a particular emphasis on integrating large-scale omics data to advance cancer research. He leads efforts to provide infrastructure and expertise for managing and analyzing genomic datasets from cutting-edge technologies, enabling investigators to leverage both experimental and public data for discoveries.
His work spans multiple cancer types, including melanoma, bladder cancer, and lung cancer, with a focus on epigenetic mechanisms, drug resistance, and biomarker development. Corcoran collaborates extensively on projects involving genomic characterization, therapeutic target identification, and translational research. Recent contributions include studies on the CALERIE Genomic Data Resource, which explores caloric restriction effects on biological aging through DNA methylation biomarkers, and investigations into the role of TET enzymes in T-cell biology and cancer suppression.
Publications highlight his expertise in omics integration, epigenetics, and precision medicine approaches, including work on exosome-based therapies for brain cancer and mechanistic studies of IDH mutations in tumor suppression. His lab actively engages in methodological advancements for genomic data analysis, such as feature selection algorithms for single-cell RNA-seq and DNA methylation-based biomarker development.
