معرفی
Daniela De Biase is an Associate Professor of Biochemistry at Sapienza University of Rome, affiliated with the Department of Medical-Surgical Sciences and Biotechnologies within the Faculty of Pharmacy and Medicine. She teaches Biochemistry across multiple degree programs including Medicine and Surgery, Dentistry, and Molecular Biology, with courses delivered both in Italian and English. Her institutional roles include serving as Vice-president of the full cycle degree course in Medicina e Chirurgia 'E' (Latina, Polo Pontino) and Coordinator of the interfaculty Monitoring Committee overseeing quality for over 90 degree courses.
Her research spans three interconnected domains: Microbiology-Molecular Biology focusing on transcriptional regulation and biochemistry of glutamate and glutamine-dependent acid resistance systems in Escherichia coli and other enteric bacteria; Biochemistry where she is an expert on PLP-dependent enzymes, particularly glutamate decarboxylase (GAD) and GABA-transaminase; and Biotechnology where she engineers GAD for biotech applications and studies acid stress response for food and biotech sector applications. Her work has evolved toward nanotechnology applications for pathogen detection and antimicrobial development, as evidenced by her recent publications.
Prof. De Biase serves on the editorial boards of several prestigious journals including Molecular Microbiology and Frontiers in Microbiology. She has organized multiple international conferences, most notably as Chair of the COST Action CA18113 'Understanding and exploiting the impacts of low pH on micro-organisms'. Her research funding includes principal investigator roles for multiple Sapienza research projects and the COST Action grant.
Her recent publications reveal a clear trajectory toward interdisciplinary research combining microbiology, biochemistry, and nanotechnology, with increasing emphasis on practical applications for pathogen detection, antimicrobial development, and medical diagnostics. The publications demonstrate a consistent focus on bacterial stress responses while expanding into novel technological applications.
- 2021: Habilitation to Full Professor BIOS-07/A (Biochemistry)
- 2010: Visiting Professor at Laboratoire de Biologie et Pharmacologie Appliquée - Ecole Normale Supérieure (ENS) de Cachan-France
- Member of Editorial Board of Molecular Microbiology (2023-present)
- Associate Editor for Frontiers in Microbiology (2017-present)
- Chair of COST Action CA18113 'Understanding and exploiting the impacts of low pH on micro-organisms' (2022-present)
Prof. De Biase leads research projects investigating carbon-phosphorus and carbon-sulfur containing amino acids and their derivatives, with applications ranging from antimicrobial development to biocatalysis. She coordinates the Internationalization Commission for the Faculty of Pharmacy and Medicine and serves as Sapienza Referent teacher and Work package Leader for Erasmus+ KA220 project 'DOMINOS'. Her laboratory facilities include the 'Laboratori di Biochimica e Biologia Molecolare delle Cellule Procariotiche e delle Cellule Eucariotiche' and 'Laboratorio Batteriologia'.
Her educational background includes a PhD in Biochemistry from the University of Wales (1991), a summa cum laude Degree in Biological Sciences from Sapienza University of Rome (1987), and classical studies from Liceo 'Giulio Cesare' in Rome (1983). She has been progressively building her academic career at Sapienza University since 1991, advancing from Assistant Professor to her current Associate Professor position.
