Daniel Sifrim

Professor Daniel Sifrim is a leading expert in gastrointestinal physiology and esophageal disorders at Queen Mary University of London, specifically affiliated with Barts and The London School of Medicine and Dentistry. With a career spanning Argentina, Belgium, and the UK, he has pioneered diagnostic techniques for gastroesophageal reflux disease (GERD) and esophageal motility disorders through innovations like high-resolution manometry and salivary pepsin measurements.

• Education: Medical degree from Buenos Aires University (1979), PhD from University of Leuven (1994)
• Awards: AGA Janssen Award 2003 for Basic and Clinical Research

His research focuses on the pathophysiology of GERD, including gastric motility, transient lower esophageal sphincter relaxations (TLESRs), and mucosal permeability. He investigates mechanisms of esophageal hypersensitivity and develops novel treatments involving mucosal protection and behavioral therapies. Recent work explores AI applications in reflux diagnostics, obesity-GERD interactions, and molecular characterization of mucosal changes.

Professor Sifrim’s publications reveal trends in three key areas: 1) Advanced diagnostic methodologies (pH-impedance monitoring, MNBI metrics), 2) Mucosal barrier dysfunction in GERD (dilated intercellular spaces, nerve growth factors), and 3) Therapeutic innovations (angico gum biopolymer, pepsin inhibitors). His work bridges clinical practice and translational research, with particular emphasis on refractory GERD and functional esophageal disorders.

Scientific Awards:

• AGA Janssen Award 2003

Teaching: Co-lead for Neurogastroenterology module in Gastroenterology MSc, PBL tutor for MBBS students, and examiner for OSCE assessments. Research Leadership: Supervises PhD candidates and collaborates with international teams on esophageal hypersensitivity and mucosal protection studies.