Daniel Mordes

Dr. Daniel Mordes is an Assistant Professor in the Department of Pathology and the Institute for Neurodegenerative Diseases (IND) at UCSF. He holds the Stuart Lindsay Professorship in Experimental Pathology IV. His research focuses on neurodegenerative diseases such as ALS, FTD, and Parkinson's, integrating human stem cell-derived neurons with patient brain samples. Key collaborators include Kevin Eggan and Stanley Prusiner. He leads labs affiliated with the Weill Institute for Neuroscience and Broad Center of Regeneration Medicine.

• Education:
  • MD and PhD in Biochemistry from Vanderbilt University School of Medicine
  • Residency/Fellowship: Neuropathology at Massachusetts General Hospital
  • Postdoc with Kevin Eggan at Harvard University/Broad Institute
• Research Interests: Combines human neuropathology with stem cell models to study neurodegenerative mechanisms. Focus areas include:
  • Heat shock protein activation in ALS/FTD
  • Single-cell RNA sequencing in neurodegeneration
  • α-synuclein prion pathogenesis
  • Stem cell-based therapeutic strategies
• Grants & Awards:
  • NINDS K08 Award (2019-2024)
  • Target ALS Collaborative Consortia Funding
  • Multiple System Atrophy Coalition Pilot Award
• Labs/Teams: Mordes Lab at UCSF IND, collaborating with Weill Neurohub and Broad Institute.