معرفی
Daniel J Murphy is a Senior Lecturer at the University of Glasgow and leads the Oncogene-Induced Vulnerabilities research group within the School of Cancer Sciences. His work focuses on understanding how oncogenes like c-Myc reprogram cellular functions to identify synthetic lethal targets and develop genetically engineered mouse models for cancer therapy evaluation.
- Education:
- PhD (2000), University of Virginia
- BSc (1993), University of Scranton
- Appointments:
- 2012–present: Senior Lecturer, University of Glasgow
- 2008–2012: Junior Group Leader, University of Würzburg
- 2006–2008: Research Specialist, University of California, San Francisco
His research explores metabolic vulnerabilities in Myc-driven tumors, emphasizing AMPK/NUAK1 kinases as therapeutic targets. He uses inducible RNAi technology to model tumor responses and investigates how oncogenes influence mitochondrial function, immune evasion, and metastasis.
Recent publications highlight trends in precision oncology (2025 Müller et al.), mesothelioma diagnostics (2024 Seyedshahi et al.), and kinase signaling adaptation (2024 Skalka et al.). His work spans pancreatic, lung, and colorectal cancers, integrating metabolic, genomic, and immune perspectives.
Scientific Awards:
- 2025–2026: Beatson Cancer Charity grant
- 2024–2029: UKRI Engineering Biology grant
- 2023–2028: Cancer Research UK grant
- 2021–2027: Medical Research Council grant
Murphy collaborates with international institutions (Oxford, Edinburgh, Imperial College London) and leads projects like REMIT and IAMMED-Meso. His lab contributes to CRUK RadNet and ACRCelerate initiatives, focusing on radiotherapy, immunometabolism, and early disease modeling in cancers.
