معرفی
Dale F. Mierke is a Professor in the Department of Chemistry at Dartmouth College. His research focuses on developing molecules to inhibit protein/protein interactions for therapeutic applications, utilizing biophysical techniques such as nuclear magnetic resonance (NMR) and fluorescence anisotropy.
- Education
- B.S., University of California at Irvine
- Ph.D., University of California at San Diego
- Post-Doc/Fulbright Fellow, Technical University of Munich
Research Interests:
- Structural characterization of therapeutic targets using NMR
- Design of molecules inhibiting DISC formation and cFLIP recruitment
- Screening for Rac1 oncogenic protein inhibitors via NMR-based GTP turnover assays
- Developing inhibitors for NEMO/IKK association to enable novel therapeutic interventions
Selected Publications Trends: His work spans structural biology, enzymatic synthesis, and therapeutic inhibition, with a focus on NMR-driven drug discovery and protein interaction dynamics.
Contact: Dale.F.Mierke@dartmouth.edu | (603) 646-1154 | Burke Room 202, HB 6128
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