معرفی
Dr. Corrie daCosta is an Assistant Professor in Chemistry and Biomolecular Sciences at the University of Ottawa. His research focuses on ligand-gated ion channel structure-function relationships, particularly their roles in physiological processes, disease, and drug interactions. He holds a PhD in Biochemistry from the University of Ottawa (2006) and completed a postdoctoral fellowship at the Mayo Clinic’s Receptor Biology Laboratory (2009–2015).
Research interests include chemical biology, ion channel pharmacology, neurophysiology, and evolutionary biochemistry. His lab employs single-molecule patch clamping and ancestral protein resurrection techniques to study molecular mechanisms and evolutionary origins of ion channel diversity.
Key recent work explores activation mechanisms in uncoupled receptors, evolutionary substitution impacts, and structural analysis of ancient ion channels. Publications span Nature Chemical Biology, PNAS, and Journal of General Physiology, emphasizing biophysical and evolutionary perspectives.
Current students include Adrian Samuel D’Costa and Christian Tessier, with notable alumni such as Blair Drummond and Johnathon Emlaw. The lab develops tools like the scbursts R package for single-channel data analysis.
No scientific awards explicitly mentioned, though contributions to ion channel research are internationally recognized. Funding supports evolutionary studies and drug-target mechanisms.
