Constantine A Gatsonis

Constantine A Gatsonis is the Henry Ledyard Goddard University Professor of Statistical Sciences and founding Director of Brown University’s Center for Biostatistics and Health Data Science. Educated at Princeton (BA) and Cornell (MS, PhD), he has been a Brown faculty member since 1995. His roles include:

• Network Statistician for ACRIN (1999–present)
• Group Statistician for ECOG-ACRIN
• Statistical Consultant for the New England Journal of Medicine (since 2016)
• Founding Editor-in-Chief of Health Services and Outcomes Research Methods
• Associate Editor for Annals of Applied Statistics and Academic Radiology

Education

• PhD, Cornell University (1981)
• MS, Cornell University (1978)
• BA, Princeton University (1976, Phi Beta Kappa)

Research Interests

Dr. Gatsonis is a world leader in statistical methods for diagnostic test evaluation and comparative effectiveness research. His work focuses on:

• ROC analysis for detection and prediction
• Bayesian methods in biomedical research
• Meta-analysis of diagnostic test accuracy
• Medical imaging biomarkers and radiomics
• Health services and outcomes research

He leads methodological development for cancer care delivery and cardiovascular disease studies through ACRIN and ECOG-ACRIN networks.

Article Trends

Dr. Gatsonis’s 250+ publications span Bayesian statistics, ROC methodology, and clinical trial design for imaging biomarkers. Key trends include:

• Development of statistical frameworks for multi-center trials (e.g., DMIST, NLST, TMIST)
• Advancements in quantitative imaging biomarkers and radiomics validation
• Focus on comparative effectiveness in cancer screening (lung, breast, cervical) and cardiovascular imaging
• Methodological contributions to meta-analysis and health technology assessment

Scientific Awards

• Fellow, American Statistical Association (1998)
• Long-Term Excellence Award, Health Policy Statistics Section, ASA (2015)
• Spinoza Visiting Professor, Academic Medical Center, University of Amsterdam (2003)
• National Research Service Award, NIMH (1986–1988)
• Fellow, Association for Health Services Research (1997)

Leadership & Grants

• Director, Brown Biostatistics Center of ACRIN (1999–present)
• Co-PI, ECOG-ACRIN Network Group Statistics and Data Management Center (U10 CA180794, 2014–2019)
• Subcontract PI, ECOG-ACRIN NCORP Research Base projects (UG1 CA189828, 2014–2025)
• Co-PI, Tomosynthesis Mammography Imaging Trial (UG1 CA189828, 2016–2025)

Labs & Collaborations

He directs the Center for Biostatistics and Health Data Science at Brown and collaborates with major networks:

• ACR Imaging Network (ACRIN, now ECOG-ACRIN)
• Quantitative Imaging Biomarkers Alliance (QIBA, RSNA)
• Cochrane Diagnostic and Screening Test Methods Working Group
• NIH/National Academies committees on forensics, reproducibility, and cancer research