Colin Jefcoate

Colin Jefcoate holds the Helmut Beinert Professor of Biological Sciences at the University of Wisconsin–Madison, focusing on cytochrome P450 enzymes and their roles in cholesterol metabolism, steroid hormone synthesis, and toxicology.

• Education: Oxford University (BA/PhD), Basel University (Postdoctoral)

Research areas include:

• P450-StAR signaling in mitochondria
• Ah receptor/PAH interactions in cancer
• MAP kinase regulation of adipogenesis
• Toxic mechanisms of arsenic and dioxin
• 3'UTR RNA stability in gene expression

Publications (2013-2017) analyze CYP1B1, StAR, and nuclear receptor pathways in liver metabolism, adipose differentiation, and environmental carcinogenesis. Techniques span CRISPR, single-cell FISH, and knockout mouse models.

Scientific contributions:

• Helmut Beinert Professorship
• Key CYP1B1-knockout studies
• Retinoid-lipogenesis crosstalk
• Cancer susceptibility in multi-potential cells

Students include J. Lee, T. Yamazaki, and M. Larsen. Research spans adrenal steroidogenesis, bone marrow toxicity, and liver metabolic diseases.