Claudia Keller Valsecchi

Claudia Keller Valsecchi is an Assistant Professor at the Biozentrum, University of Basel, where her research group will commence in August 2025. Her work focuses on epigenetic mechanisms of gene dosage compensation and sex chromosome regulation across species, with implications for development, evolution, and disease.

Her research interests lie at the intersection of epigenetics, developmental biology, and evolutionary genomics. She investigates how cells regulate gene dosage in response to sex chromosome differences, particularly in male and female animals. Her work explores tissue-specific escape from X-chromosome inactivation in humans, the role of the male-specific SOA factor in mosquito dosage compensation, and the impact of environmental factors like temperature on sex determination in crustaceans. These studies contribute to understanding sex-biased diseases and the evolutionary dynamics of gene regulation.

Her recent publications, spanning journals like Nature and Genes & Development, reflect a strong focus on chromatin dynamics, RNA-mediated regulation, and dosage compensation mechanisms across diverse organisms. Key themes include m6A methylation in RNA stability, MSL complex function, and comparative analysis of dosage compensation in insects and mammals.

Scientific awards received include:

• Friedrich Miescher Award
• EMBO Young Investigator

She leads a research group at the Biozentrum, University of Basel, focusing on epigenetic regulation and gene dosage. While specific advisees are not listed, her collaborative publications suggest active mentorship and grant-funded research in molecular and evolutionary epigenetics.