Claude Chapman

Claude Chapman, PhD is a Professor at the University of California, San Francisco (UCSF) School of Medicine, Department of Medicine. Their research focuses on cellular senescence, pulmonary fibrosis, and TGF-β/Wnt signaling in lung diseases.

• Education: PhD in Cell and Molecular Biology (1996), Universite de Provence
• Training: MENG (Microbiology & Biotechnology), MS (Cell and Molecular Biology), BS (Biochemistry & Microbiology)

Key research themes include:

• Mechanisms of idiopathic pulmonary fibrosis (IPF) initiation via senescent alveolar epithelial cells
• Role of senolytic drugs in fibrosis resolution
• HLA-E-mediated immune evasion by senescent cells
• Interplay between TGF-β, Wnt pathways, and LOXL2 in fibrotic processes

Recent publications analyze:

• 2024 - Fibroblast-driven epithelial metaplasia in IPF via noncanonical Wnt signaling
• 2023 - BCL-2 modulation of ER stress in fibrosis
• 2021 - LOXL2 inhibition promoting collagen turnover in IPF

Awards include:

• 2025 - ATS Fellow
• 2014 - Carol Basbaum Award
• 2012 - Young Investigator Award

Grants: NIH R21AG052744 (2016-2019) on senescent cells in aging lungs.