Claire M.S. Michielsen

Claire M.S. Michielsen is a postdoctoral researcher at Eindhoven University of Technology, affiliated with the Applied Physics and Science Education unit and specializing in Molecular Biosensing. Her work bridges physics and biochemistry to develop advanced biosensor technologies.

• Education: Master's degree (2021) with thesis on BRET-based zinc sensors
• Current project: Real-time Biomolecular Sensing for Smart Food Industry (2021-2026)

Research Interests
Michielsen focuses on creating bioluminescent and particle motion-based biosensors for real-time biomolecular monitoring. Her work spans:

• Zinc ion quantification in biological systems
• Infectious disease diagnostics using CRISPR/Cas9
• Protein sensing via antibody fragment dynamics
• TNF-α monitoring for inflammatory diseases
• Optimization of biosensor kinetics
• Applications in food safety and medical diagnostics

Research Trends
Her publications demonstrate expertise in integrating biophysics with molecular biology, particularly through:

• Particle motion analysis for biosensing
• Split luciferase systems for disease detection
• Ratiometric bioluminescence for metal ion monitoring
• Antibody fragment engineering
• Continuous monitoring platforms
• Surface plasmon resonance applications

Collaborations
Works closely with:

• Prof. Maarten W.J. Prins
• Dr. Anna M. de Jong
• Prof. Marc Merkx