Christopher Brown

Christopher Brown serves as a Clark Scholar and instructor in the Department of Neurology at the University of Pennsylvania, where he conducts clinical training at the Penn Memory Center under Dr. Dave Wolk's mentorship. His work bridges neurology, imaging science, and neurodegenerative disease research within Penn's academic medical ecosystem.

His educational trajectory includes a bachelor's degree in biology and philosophy-neuroscience-psychology from Washington University in St. Louis, followed by dual MD/PhD training at the University of Kentucky. His doctoral research focused on multimodal imaging in aging and preclinical Alzheimer's disease, specifically examining executive function decline.

Dr. Brown's research centers on multimodal neuroimaging approaches to map neurodegenerative pathology propagation through white matter networks. His work integrates advanced MRI techniques with computational analysis to understand Alzheimer's disease mechanisms, emphasizing the structural connectivity basis of cognitive decline. This focus positions him at the intersection of clinical neurology and cutting-edge imaging methodology development.

Analysis of his 2024-2025 publications reveals dominant themes in Alzheimer's disease genetics (particularly variant-to-function mapping in microglial models), high-resolution neuroimaging segmentation, and white matter microstructure analysis. His work consistently connects molecular mechanisms with structural brain changes, using techniques ranging from 7T MRI to multi-ancestry genetic studies.

His scientific recognition includes:

• Clark Scholar award

As a Penn Memory Center researcher, Dr. Brown contributes to collaborative projects investigating early Alzheimer's detection biomarkers. His current work extends into glymphatic system research and vascular contributions to neurodegeneration, supported by institutional resources within Penn's neuroscience infrastructure.

He operates within the Penn Memory Center's research ecosystem, which integrates clinical care with translational neuroscience to advance dementia diagnosis and treatment through multidisciplinary team science.