معرفی
Christine Tardif is an Assistant Professor in the Department of Biomedical Engineering and the Department of Neurology and Neurosurgery at McGill University. As head of the McConnell Brain Imaging Centre lab at the Montreal Neurological Institute, she develops advanced MRI techniques for in-vivo brain imaging, focusing on quantitative mapping of myelin and cortical microstructure. Her work spans methodological innovation (e.g., multi-modal biophysical modeling) and translational applications across preclinical (7 Tesla) and clinical (3 and 7 Tesla) systems.
- Undergraduate: B.Eng. in Computer Engineering, McGill University (2004)
- Master's: M.Sc. in Bioengineering, Imperial College London (2006)
- PhD: Biomedical Engineering, McGill University (2011)
Her research explores myelin dynamics in health and disease, emphasizing its role in neural conduction, brain plasticity, and cognitive functions. The lab investigates dysmyelination in psychiatric disorders (e.g., bipolar disorder) and neurodegenerative conditions (e.g., multiple sclerosis) using relaxometry, magnetization transfer, and diffusion-weighted imaging. Recent methodological work includes 3D MERMAID sequences for motion-insensitive diffusion imaging and optimization of magnetization transfer saturation maps.
Current projects integrate ultra-high field MRI with histological validation in preclinical models (e.g., marmoset brain sections), aiming to bridge microstructural metrics with macro-scale brain function. Applications span Alzheimer's disease risk assessment via white matter alterations, synaptic density mapping in psychosis, and cortical laminar differentiation studies.
