Christine Baldeschi

Christine Baldeschi is a Lecturer at University of Evry, where she has been working since September 2006. She leads a research team at the Stem Cell Institute for the treatment and study of monogenic diseases (i-Stem - Inserm/University d'Evry), focusing on the development of skin cell therapies for rare genetic diseases.

Her educational background includes a Master's degree in cellular and molecular biology from Nice Sophia Antipolis University, followed by doctoral research completed in 2004. She then conducted post-doctoral studies in Glasgow before returning to France to join University of Evry at age 29.

Dr. Baldeschi specializes in stem cell applications for treating rare genetic skin disorders. Her work involves developing protocols to differentiate pluripotent stem cells into various skin cell types including keratinocytes, melanocytes, and fibroblasts. She is particularly known for her work on genodermatoses with two primary research directions:

• Developing cell therapies for sickle cell disease, with upcoming clinical trials aiming to graft lab-grown epidermis onto patients suffering from leg ulcers
• Pathological modeling of epidermolysis bullosa using reprogrammed blood cells to study disease mechanisms and test potential treatments

As an educator, she directs the M2 tissue, cell and gene biotherapy program, mentoring the next generation of researchers in this specialized field. Her team collaborates closely with medical professionals at Necker Hospital to translate laboratory findings into potential clinical applications, with current work described as being 'closer than ever' to treating patients with these rare conditions.